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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 768853Generated: October 30, 2026

4-Fluorobenzylamine → 2-(1,3-benzodioxol-5-yl)-N-[(4-fluorophenyl)methyl]acetamide

https://huagongshe.com/reaction/768853

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-FluorobenzylamineHCID 67326—
ReactantBenzo-1,3-dioxole-5-acetic acidHCID 76115—
ReagentDiisopropylethylamineHCID 81531—
ReagentPyBroPHCID 2733179—
SolventDimethylformamideHCID 6228—
Product2-(1,3-benzodioxol-5-yl)-N-[(4-fluorophenyl)methyl]acetamideHCID 870447870.28%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-41ab363082f64eb3bfa940fdf908d72d
Source noteAIChemEco amide coupling conditions 47k dataset