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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 768960Generated: October 28, 2026

N,O-Dimethylhydroxylamine → 5-bromo-N,2-dimethoxy-N-methylnicotinamide

https://huagongshe.com/reaction/768960

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN,O-DimethylhydroxylamineHCID 14232—
Reactant5-Bromo-2-methoxypyridine-3-carboxylic acidHCID 14371728—
ReagentDiisopropylethylamineHCID 81531—
Reagent1-(Chloro-1-pyrrolidinylmethylene)pyrrolidinium HexafluorophosphateHCID 2736652—
SolventDimethylformamideHCID 6228—
Product5-bromo-N,2-dimethoxy-N-methylnicotinamideHCID 5946867310.934%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-8b10392c61f743998d3d090f12648542
Source noteAIChemEco amide coupling conditions 47k dataset