反应详情

The title compound of step 2 (43.3 g, 217 mmol) and ethylene glycol (27.4 g, 435 mmol) were boiled in toluol (430 mL) with the addition of p-toluol sulphonic acid (1.87 g, 10.9 mmol) at a water separator for 3 h with reflux. After the reaction had ended, the mixture was cooled, washed with NaHCO3 solution and saturated NaCl solution, dried with Na2SO4 and concentrated to low volume in a vacuum.

1. temperaturewith reflux
2. temperaturethe mixture was cooled
3. washwashed with NaHCO3 solution and saturated NaCl solution
4. dry with materialdried with Na2SO4
5. concentrationconcentrated to low volume in a vacuum