Hydrochloric Acid → 4-Benzyl-4-dimethylaminomethyl-1-methylamino-cyclohexane carbonitrile

Participants

Reaction Conditions

Reaction Steps

40% aqueous methylamine solution (15.3 mL, 121 mmol) and 4-benzyl-4-((dimethylamino)methyl)cyclohexanone (6.20 g, 25.3 mmol) dissolved in methanol (25 mL) were added to a solution of 4N hydrochloric acid (6.6 mL) and methanol (4.00 mL) cooled to 0° C. The reaction mixture was then mixed with potassium cyanide (4.00 g, 60 mmol) and stirred for 5 d at room temperature. For work up the mixture was diluted with water (180 mL) and extracted with ether (3×100 mL). The combined organic phases were dried over Na2SO4, filtered and concentrated until dry in a vacuum.

Provenance & Evidence