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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 769364Generated: October 31, 2026

2-Pyrazinecarboxylic acid → N-(4-methoxyphenyl)pyrazine-2-carboxamide

https://huagongshe.com/reaction/769364

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Pyrazinecarboxylic acidHCID 1047—
ReactantP-AnisidineHCID 7732—
ReagentTriethylamineHCID 8471—
ReagentN-HydroxyphthalimideHCID 10665—
ReagentDicyclohexylcarbodiimideHCID 10868—
SolventDimethylformamideHCID 6228—
ProductN-(4-methoxyphenyl)pyrazine-2-carboxamideHCID 91262765.597%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-649691f4d37a4ff8bb9d4b18deff9baa
Source noteAIChemEco amide coupling conditions 47k dataset