反应详情

A solution of the title compound from Example 69 (111 mg, 0.33 mmol) and formalin (0.45 mL, 37% aqueous solution) in acetonitrile (3 mL) was mixed with sodium cyanoboron hydride (83 mg, 1.32 mmol) and stirred for 45 min at RT. Conc. acetic acid was then added until a neutral reaction occurred and the mixture stirred for 45 min at RT. For work up the solvent was removed in a vacuum, the residue taken up with 2N NaCl (5 mL) and then extracted with ether (3×10 mL). The organic solution was dried over Na2SO4 and concentrated to low volume in a vacuum. The remaining residue was purified by means of flash chromatography with ethyl acetate/methanol (1:2→MeOH).

1. stirringthe mixture stirred for 45 min at RT
2. customFor work up the solvent was removed in a vacuum
3. extractionextracted with ether (3×10 mL)
4. dry with materialThe organic solution was dried over Na2SO4
5. concentrationconcentrated to low volume in a vacuum
6. customThe remaining residue was purified by means of flash chromatography with ethyl acetate/methanol (1:2→MeOH)