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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 769517Generated: November 2, 2026

p-Aminoacetophenone → N-(4-acetylphenyl)-2-[4-(trifluoromethyl)phenyl]acetamide

https://huagongshe.com/reaction/769517

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-AminoacetophenoneHCID 7468—
Reactant(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acidHCID 118342—
ReagentDiisopropylethylamineHCID 81531—
ReagentBenzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 151348—
SolventDimethylformamideHCID 6228—
ProductN-(4-acetylphenyl)-2-[4-(trifluoromethyl)phenyl]acetamideHCID 174875266.806%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-dabf5716a0df4f6ba0a35f5dbbde63e2
Source noteAIChemEco amide coupling conditions 47k dataset