反应详情

To a solution of 3-fluorophenyl acetic acid (10.0 g, 64.9 mmol) in ethanol (300 mL), is added a catalytic amount of H2SO4 (98%, 1 mL) and the mixture reacted for 12 hours at 100° C. (LC-MS monitoring: complete conversion). The solvent is evaporated and the residue is partitioned between EtOAc and water; the organic layer is separated and dried over Na2SO4 in order to obtain 10.1 g of (I8) as a white solid (85% yield).

1. customthe mixture reacted for 12 hours at 100° C. (LC-MS monitoring: complete conversion)
2. customThe solvent is evaporated
3. customthe residue is partitioned between EtOAc and water
4. customthe organic layer is separated
5. dry with materialdried over Na2SO4 in order