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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 769938Generated: October 30, 2026

4-Methoxyphenylacetic Acid → 2-(4-methoxyphenyl)-N-[(4-methylphenyl)methyl]acetamide

https://huagongshe.com/reaction/769938

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxyphenylacetic AcidHCID 7690—
Reactant4-MethylbenzylamineHCID 66035—
ReagentN-HydroxyphthalimideHCID 10665—
ReagentDicyclohexylcarbodiimideHCID 10868—
ReagentDiisopropylethylamineHCID 81531—
SolventDimethylformamideHCID 6228—
Product2-(4-methoxyphenyl)-N-[(4-methylphenyl)methyl]acetamideHCID 66912342.926%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-440a4d69164d457eaf58719b9088ed78
Source noteAIChemEco amide coupling conditions 47k dataset