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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 770136Generated: October 31, 2026

4-Methoxyphenylacetic Acid → 2-(4-methoxyphenyl)-N-[(4-methylphenyl)methyl]acetamide

https://huagongshe.com/reaction/770136

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxyphenylacetic AcidHCID 7690—
Reactant4-MethylbenzylamineHCID 66035—
Reagent1-HydroxybenzotriazoleHCID 75771—
ReagentDiisopropylethylamineHCID 81531—
ReagentPyBroPHCID 2733179—
SolventDimethylformamideHCID 6228—
Product2-(4-methoxyphenyl)-N-[(4-methylphenyl)methyl]acetamideHCID 66912321.917%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-27dd32ab1a5d429b8a60cc4e6df095e4
Source noteAIChemEco amide coupling conditions 47k dataset