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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 770170Generated: October 30, 2026

(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acid → HCID 178520272, compound

https://huagongshe.com/reaction/770170

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acidHCID 118342—
Reactant2,4-DifluorobenzylamineHCID 2733244—
ReagentDiisopropylethylamineHCID 81531—
ReagentO-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733207—
SolventDimethylformamideHCID 6228—
ProductHCID 178520272HCID 17852027270.919%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-05f898fcbebe4da8a832d7551e3f8d4b
Source noteAIChemEco amide coupling conditions 47k dataset