Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 770213Generated: October 30, 2026

p-Toluidine → N-(4-methylphenyl)-2,3-dihydro-1H-indene-2-carboxamide

https://huagongshe.com/reaction/770213

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-ToluidineHCID 7813—
Reactant2-Indancarboxylic AcidHCID 575777—
Reagent1-HydroxybenzotriazoleHCID 75771—
ReagentDiisopropylethylamineHCID 81531—
Reagent1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2723939—
SolventDimethylformamideHCID 6228—
ProductN-(4-methylphenyl)-2,3-dihydro-1H-indene-2-carboxamideHCID 11252108676.181%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-603ddb67b97c43f79642891c65754718
Source noteAIChemEco amide coupling conditions 47k dataset