反应详情

温度

0 °C

Ethyl 2-oxo-2-(4-(trifluoromethyl)phenyl)acetate (500 mg, 2.03 mmol) is dissolved in absolute EtOH (10 mL) and cooled at 0° C. under N2. NaBH4 (38.4 mg, 1.02 mmol) is added in two portions and the resulting suspension is allowed to warm to RT and stirred for 45 minutes. The solvent is evaporated, the resulting residue is diluted with Et2O and cool water is added. The organic layer is separated, washed with water and brine, dried over Na2SO4, filtered and evaporated obtaining intermediate I149 as a colorless oil (440 mg, 87% yield).

1. temperatureto warm to RT
2. customThe solvent is evaporated
3. additionthe resulting residue is diluted with Et2O
4. temperaturecool water
5. additionis added
6. customThe organic layer is separated
7. washwashed with water and brine
8. dry with materialdried over Na2SO4
9. filtrationfiltered
10. customevaporated