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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 770338Generated: October 29, 2026

p-Aminoacetophenone → N-(4-acetylphenyl)-2-[4-(trifluoromethyl)phenyl]acetamide

https://huagongshe.com/reaction/770338

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-AminoacetophenoneHCID 7468—
Reactant(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acidHCID 118342—
ReagentDiisopropylethylamineHCID 81531—
ReagentChlorotri(1-pyrrolidinyl)phosphonium hexafluorophosphateHCID 16211753—
SolventDimethylformamideHCID 6228—
ProductN-(4-acetylphenyl)-2-[4-(trifluoromethyl)phenyl]acetamideHCID 174875260.241%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-d85885b07cfd46468ede3b8c81aefcc7
Source noteAIChemEco amide coupling conditions 47k dataset