反应详情

温度

100 °C

2-Bromo-2-(4-chlorophenyl)acetic acid (1.2 g, 4.67 mmol) and aniline (0.85 mL, 9.33 mmol) are dissolved in acetonitrile (29 mL). The reaction is heated under microwave irradiation at 100° C. for 5 minutes. The solvent is evaporated and the residue is dissolved in EtOAc and washed with 3M HCl and then brine. The organic layer is dried over Na2SO4, filtered and evaporated to dryness to give intermediate I258 as a white solid (1.22 g, quantitative yield).

1. customThe solvent is evaporated
2. dissolutionthe residue is dissolved in EtOAc
3. washwashed with 3M HCl
4. dry with materialThe organic layer is dried over Na2SO4
5. filtrationfiltered
6. customevaporated to dryness