N-(2-Amino-5-fluoro-phenyl)-5-bromo-2-chloro-benzamide → HCID 178505463, compound

HRID 77073Notes

Reaction equation

HRID 77073 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[NH:9][C:10](=O)[C:11]1[CH:16]=[C:15]([Br:17])[CH:14]=[CH:13][C:12]=1[Cl:18]>C(O)(=O)C>[Br:17][C:15]1[CH:14]=[CH:13][C:12]([Cl:18])=[C:11]([C:10]2[NH:1][C:2]3[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=3[N:9]=2)[CH:16]=1

Participants

3

Reactant 1

HCID 63257336N-(2-Amino-5-fluoro-phenyl)-5-bromo-2-chloro-benzamide

Product 1

HCID 178505463HCID 178505463, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Method 3,4—Step b A solution of N-(2-Amino-5-fluoro-phenyl)-5-bromo-2-chloro-benzamide (6.90 g, 20.12 mmol) in acetic acid (40 mL) was stirred at 80° C. overnight, solvent was then removed under reduced pressure and the crude purified by precipitation from diethylether to obtain 6.00 g of the title compound (92%).

Workup

  1. customsolvent was then removed under reduced pressure
  2. customthe crude purified by precipitation from diethylether

Sources & evidence

ORD record
ord-ed40964a733b4b15a0823cfd54635c3f
Source dataset
uspto-grants-2014_09
Patent number
US08835648B2

Reaction notes

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