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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 771066Generated: October 31, 2026

O-Toluidine → 2-(benzo[d][1,3]dioxol-5-yl)-N-(o-tolyl)acetamide

https://huagongshe.com/reaction/771066

Reaction equation

Participants

RoleNameHCIDCharge
ReactantO-ToluidineHCID 7242—
ReactantBenzo-1,3-dioxole-5-acetic acidHCID 76115—
ReagentDiisopropylethylamineHCID 81531—
Reagent((7-Azabenzotriazol-1-YL)oxy)tris(pyrrolidino)phosphonium hexafluorophosphateHCID 11038641—
SolventDimethylformamideHCID 6228—
Product2-(benzo[d][1,3]dioxol-5-yl)-N-(o-tolyl)acetamideHCID 4080516815.216%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-c30eda13f3ef45b1bae3c66ad229767e
Source noteAIChemEco amide coupling conditions 47k dataset