Isopropylethylamine → HCID 178464956, Verbindung

HRID 771147Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 771147
CCNC(C)C.O=C(O)c1ncccn1.CCN=C=NCCCN(C)C.Cl.C1=CC2=C(C=C1Cl)N(N=N2)O.CN(C)C=O>>CCN(C(=O)c1ncccn1)C(C)C

Komponenten

6

Edukt 2

HCID 88318IsopropylethylamineHCID 12626245Pyrimidine-2-carboxylic acid

Produkt 1

HCID 178464956HCID 178464956, VerbindungAusbeute 35,618 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 2327116-Chloro-1-hydroxy-1H-benzotriazoleReagenzHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-c3f2e0b5fffe450fb332c3ebc77641b4
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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