HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl Peroxide → 2-[4-(Bromomethyl)-3-(methoxymethoxy)phenyl]-1,3-benzoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl Peroxide | HCID 7187 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 2-[3-(Methoxymethoxy)-4-methylphenyl]-1,3-benzoxazole | HCID 21991002 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 2-[4-(Bromomethyl)-3-(methoxymethoxy)phenyl]-1,3-benzoxazole | HCID 21990942 | — |
Reaction Steps
A solution of 2-[3-(methoxymethoxy)-4-methylphenyl]-1,3-benzoxazole (200 mg, 0.74 mmol, 84%), NBS (179 mg, 0.81 mmol), and benzoyl peroxide (50 mg) in CCl4 (10 mL), was refluxed for 12 h. After cooling to rt, CCl4 was removed in vacuo and residue was purified by flash column (silica gel, hexanes:EtOAc 5:1) to afford 2-[4-(bromomethyl)-3-(methoxymethoxy)phenyl]-1,3-benzoxazole. MS (ESI) 349 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07087601B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-3fbdb02c28694b2ab3cd6d303a6d36e5 |
| Source note | uspto-grants-2006_08 |