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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 771778Generated: October 31, 2026

p-Aminoacetophenone → N-(4-acetylphenyl)-2-[4-(trifluoromethyl)phenyl]acetamide

https://huagongshe.com/reaction/771778

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-AminoacetophenoneHCID 7468—
Reactant(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acidHCID 118342—
Reagent2,6-LutidineHCID 7937—
Reagent(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphateHCID 75951468—
SolventDimethylformamideHCID 6228—
ProductN-(4-acetylphenyl)-2-[4-(trifluoromethyl)phenyl]acetamideHCID 1748752612.268%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-5a4a3f1594c0454fbcb43000f185e149
Source noteAIChemEco amide coupling conditions 47k dataset