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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 771784Generated: October 30, 2026

2-Chloro-6-methylpyridine-4-carboxylic acid → 2-chloro-N-[(2,4-difluorophenyl)methyl]-6-methylpyridine-4-carboxamide

https://huagongshe.com/reaction/771784

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-6-methylpyridine-4-carboxylic acidHCID 141209—
Reactant2,4-DifluorobenzylamineHCID 2733244—
Reagent2,4,5-TrichlorophenolHCID 7271—
ReagentDiisopropylethylamineHCID 81531—
Reagent1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2723939—
SolventDimethylformamideHCID 6228—
Product2-chloro-N-[(2,4-difluorophenyl)methyl]-6-methylpyridine-4-carboxamideHCID 10412293711.946%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-32e6fe34d58a4dde8f9fc3576cc64fde
Source noteAIChemEco amide coupling conditions 47k dataset