Sorbitol → Tamsulosin

Participants

Reaction Steps

An amount of 36.3 mg Tamsulosin hydrochloride was added at 60° C. to 50 ml of aqueous solution containing 1.5 g of sodium alginate (Protanal LF, FMC Biopolymer) and 350 mg of sorbitol. The resulting solution was cast on two 9 cm-diameter polyester Petri dishes and dried at ambient temperature under constant airflow in a chemical hood. The dried film was tested for oral disintegration acceptance (taste, adhesion and disintegration rate). The film was found to have slight bitter taste, to have good adhesion to roof of the mouth, and oral cavity disintegration of less then one minute.

Provenance & Evidence