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HRID77262

反应详情

EQUATION

反应方程式

HRID 77262 的结构方程式

REACTANTS

反应物

1
结构：COC(=O)[C@@H]1C[C@@]2(CN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCCN1C(C)C)C1CCCCC1)C(C)(C)C)C(C)(C)C21CCC1
HCID59533292

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)N1CCCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N1C[C@]2(C[C@H]1C(=O)O)C(C)(C)C21CCC1)C(C)(C)C)C1CCCCC1
HCID59533288

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1.CO.O
溶剂HCID21892291

未命名化合物

PROCEDURE

实验过程

To a solution of (5R,8S)-7-((S)-2-{(S)-2-Cyclohexyl-2-[((S)-1-isopropyl-piperidine-2-carbonyl)-amino]-acetylamino}-3,3-dimethyl-butyryl)-10,10-dimethyl-7-aza-dispiro[3.0.4.1]decane-8-carboxylic acid methyl ester (0.69 g; 1.10 mmol) in THF/Methanol/water (2:1:1; 20 mL) was added LiOH monohydrate (0.138 g; 3.3 mmol) and the reaction was stirred overnight at room temperature. The solvent was removed in vacuo, water was added, the product was frozen in liquid nitrogen and lyophilized overnight to yield the title compound. LC-MS (method E): Rt=1.50 min; M/z=615 [M+]; HPLC (method A3): Rt=4.38 min

WORKUP

后处理

  1. customThe solvent was removed in vacuo, water
  2. additionwas added
  3. temperaturethe product was frozen in liquid nitrogen
  4. waitlyophilized overnight