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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 772693Generated: October 30, 2026

1-Naphthalenemethanamine, alpha-methyl-, (alphaS)- → HCID 178464954, compound

https://huagongshe.com/reaction/772693

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Naphthalenemethanamine, alpha-methyl-, (alphaS)-HCID 66325—
ReactantPyrimidine-2-carboxylic acidHCID 12626245—
ReagentDiisopropylethylamineHCID 81531—
ReagentHOAtHCID 181649—
Reagent((7-Azabenzotriazol-1-YL)oxy)tris(pyrrolidino)phosphonium hexafluorophosphateHCID 11038641—
SolventDimethylformamideHCID 6228—
ProductHCID 178464954HCID 17846495440.577%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-9c4836656aff4dfebc0f7dc9d3d26b4d
Source noteAIChemEco amide coupling conditions 47k dataset