Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Toluenesulfonic acid → 2-(Morpholin-4-yl)methyl-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | 2-Hydroxymethyl-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane | HCID 66701518 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2-(Morpholin-4-yl)methyl-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane | HCID 70656453 | — |
반응 단계
2-hydroxymethyl-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane (Compound 1.50 gm, 0.18 mole), Para Toluenesulfonic Acid (PTSA, 3.5 gms) was dissolved in toluene (300 ml) at 28° C. To this was added 18.5 gm of morpholine drop wise with continuous stirring, continued the stirring for 13 hrs at reflux temperature. Toluene was distilled under vacuum to get a semi-solid with brick red color. The yield of the product was 90%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841296B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-4414bb4f86ae4421ad6735ac5301fd31 |
| 출처 메모 | uspto-grants-2014_09 |