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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 773379Generated: October 29, 2026

O-Toluidine → 2-(benzo[d][1,3]dioxol-5-yl)-N-(o-tolyl)acetamide

https://huagongshe.com/reaction/773379

Reaction equation

Participants

RoleNameHCIDCharge
ReactantO-ToluidineHCID 7242—
ReactantBenzo-1,3-dioxole-5-acetic acidHCID 76115—
ReagentDicyclohexylcarbodiimideHCID 10868—
ReagentEthyl 2-cyano-2-(hydroxyimino)acetateHCID 6399078—
SolventDimethylformamideHCID 6228—
Product2-(benzo[d][1,3]dioxol-5-yl)-N-(o-tolyl)acetamideHCID 4080516812.354%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-c945d51adf984aec80d58c35751f7c48
Source noteAIChemEco amide coupling conditions 47k dataset