HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 77342Generated: October 25, 2026
Potassium Carbonate → 1-(2-Chloro-5-thiazolylmethyl)piperidine 4-one
https://huagongshe.com/reaction/77342
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloro-5-chloromethylthiazole | HCID 2763179 | — |
| Reactant | Piperidin-2-one--hydrogen chloride (1/1) | HCID 20088740 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-(2-Chloro-5-thiazolylmethyl)piperidine 4-one | HCID 70655845 | — |
Reaction Steps
25 gm of piperidone hydrochloride was taken in 250 ml acetonitrile. 68.7 gm of K2CO3 was added under stirring at 60° C., followed by addition of 27.8 gm of 2-chloro-5-chloromethylthiazole and refluxed for 6 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08841296B2 |
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| Source dataset | uspto-grants-2014_09 |
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| ORD ID | ord-0e71ca6a87394df3ad9714f21e115bdd |
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| Source note | uspto-grants-2014_09 |
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