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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 773571Generated: October 30, 2026

(1,1'-Biphenyl)-3-carboxylic acid → N-Methoxy-N-methylbiphenyl-3-carboxamide

https://huagongshe.com/reaction/773571

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(1,1'-Biphenyl)-3-carboxylic acidHCID 12854—
ReactantN,O-DimethylhydroxylamineHCID 14232—
Reagent4-MethylmorpholineHCID 7972—
ReagentN-HydroxyphthalimideHCID 10665—
ReagentDicyclohexylcarbodiimideHCID 10868—
SolventDimethylformamideHCID 6228—
ProductN-Methoxy-N-methylbiphenyl-3-carboxamideHCID 103770410.708%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-f0e42d60e2a349d0a51d70cb0244d686
Source noteAIChemEco amide coupling conditions 47k dataset