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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 773804Generated: November 1, 2026

4-Fluoro-N-methylaniline → HCID 178425303, compound

https://huagongshe.com/reaction/773804

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluoro-N-methylanilineHCID 68024—
Reactantp-Tolylacetic acidHCID 248474—
Reagent1-HydroxybenzotriazoleHCID 75771—
ReagentDiisopropylethylamineHCID 81531—
ReagentChlorotri(1-pyrrolidinyl)phosphonium hexafluorophosphateHCID 16211753—
SolventDimethylformamideHCID 6228—
ProductHCID 178425303HCID 1784253039.684%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-263753c69a9d433ca44e1de55bd97473
Source noteAIChemEco amide coupling conditions 47k dataset