HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-methyl-5-nitroisonicotinamide → 5-amino-2-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-methylisonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-methyl-5-nitroisonicotinamide | HCID 67114970 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-amino-2-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-methylisonicotinamide | HCID 67115060 | — |
Reaction Steps
To a solution of 2-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-methyl-5-nitroisonicotinamide (Intermediate 28A) (50 mg, 0.16 mmol) in methanol (0.3 mL) under nitrogen was added palladium on carbon (25 mg). Reaction subjected to a hydrogen atmosphere and stirred overnight. The reaction mixture was filtered and concentrated to afford 5-amino-2-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-methylisonicotinamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08841289B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-346cfba2afa64bdea8d932b0d864ea1d |
| Source note | uspto-grants-2014_09 |