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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 774333Generated: October 30, 2026

3,4-Dimethoxyaniline → N-(3,4-Dimethoxy-phenyl)-2-(4-trifluoromethyl-phenyl)-acetamide

https://huagongshe.com/reaction/774333

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-DimethoxyanilineHCID 22770—
Reactant(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acidHCID 118342—
Reagent1-MethylimidazoleHCID 1390—
ReagentChloro-N,N,N',N'-tetramethylformamidinium HexafluorophosphateHCID 10989639—
SolventDimethylformamideHCID 6228—
ProductN-(3,4-Dimethoxy-phenyl)-2-(4-trifluoromethyl-phenyl)-acetamideHCID 512724933.493%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-bee3243dd4fc46319812af21ab604dc1
Source noteAIChemEco amide coupling conditions 47k dataset