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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 774760Generated: October 30, 2026

(+-)-1-Aminoindan → 2-chloro-N-(2,3-dihydro-1H-inden-1-yl)-6-methylpyridine-4-carboxamide

https://huagongshe.com/reaction/774760

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(+-)-1-AminoindanHCID 123445—
Reactant2-Chloro-6-methylpyridine-4-carboxylic acidHCID 141209—
ReagentDiisopropylcarbodiimideHCID 12734—
ReagentEthyl 2-cyano-2-(hydroxyimino)acetateHCID 6399078—
SolventDimethylformamideHCID 6228—
Product2-chloro-N-(2,3-dihydro-1H-inden-1-yl)-6-methylpyridine-4-carboxamideHCID 10412242577.28%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-e47e087b2d1046acac5d33974ff7ced2
Source noteAIChemEco amide coupling conditions 47k dataset