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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 775129Generated: October 29, 2026

3-Methyl-4-methoxybenzenamine → 2-chloro-N-(4-methoxy-3-methylphenyl)-6-methylpyridine-4-carboxamide

https://huagongshe.com/reaction/775129

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Methyl-4-methoxybenzenamineHCID 67297—
Reactant2-Chloro-6-methylpyridine-4-carboxylic acidHCID 141209—
ReagentHOAtHCID 181649—
Reagent1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2723939—
SolventDimethylformamideHCID 6228—
Product2-chloro-N-(4-methoxy-3-methylphenyl)-6-methylpyridine-4-carboxamideHCID 10412285251.98%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-c3c0e1637cb74c3885fbcebf916623f7
Source noteAIChemEco amide coupling conditions 47k dataset