Hydrochloric Acid → HCID 178479361, compound

Participants

Reaction Steps

A mixture of 140 mg (0.22 mmol) (S)-1-[((S)-1-tert-butoxycarbonyl-2-phenyl-ethylcarbamoyl)-methyl]-3-[N′-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-1-azonia-bicyclo-[2.2.2]-octane chloride (Intermediate 59) and 6.2 mL (12.4 mmol) HCl (2 M) in diethyl ether is stirred overnight at room temperature. The resulting solid is collected by filtration and washed with diethyl ether. Recrystallization from acetone yields the title compound (78 mg).

Provenance & Evidence