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1-(4-Aminophenyl)methanesulfonamide → {4-[4-(2-Methoxy-phenyl)-pyrimidin-2-ylamino]-phenyl}-methanesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(4-Aminophenyl)methanesulfonamide | HCID 10821407 | — |
| 反応物 | 2-Chloro-4-(2-methoxyphenyl)pyrimidine | HCID 24901882 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | {4-[4-(2-Methoxy-phenyl)-pyrimidin-2-ylamino]-phenyl}-methanesulfonamide | HCID 25022386 | — |
反応手順
A solution of 2-chloro-4-(2-methoxy-phenyl)-pyrimidine (0.883 g, 0.004 mol), and (4-amino-phenyl)-methanesulfonamide (0.745 g, 0.004 mol) (Bosch, J.; Roca, T. et al., Tetrahedron (2001), 57(6), 1041-1048. Owa, Takashi et al., Journal of Med. Chem. (1999), 42(19), 3789-3799) in DMF (12 ml) was stirred for 2 hours at 80° C. (TLC control). The solvent was removed under reduced pressure to afford {4-[4-(2-Methoxy-phenyl)-pyrimidin-2-ylamino]-phenyl}-methanesulfonamide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08841315B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-ab2fca0a89e84f15a83e5ca6091dbfc0 |
| 出典メモ | uspto-grants-2014_09 |