反应详情

温度

65 °C

A 5-L reaction vessel was charged with methanol (3.3 L), sodium methoxide (102.4 g, 1.8 moles), and glycinamide hydrochloride (202 g, 1.8 moles). The mixture was heated at 65° C. for 1 hour before cooling to 50° C. and adding acetic acid (514.25 mmoles, 30.88 g, 29.47 mL) and ethyl 3-(5-chloro-2-methoxyphenyl)-3-oxopropanoate (300 g, 1.03 mole). After heating to reflux for 16 hours, the reaction mixture was stirred as it was cooled to 10° C. After 30 min the resulting solid was collected by vacuum filtration, pulling dry to form a cake that was dried in a vacuum oven (20 mm Hg, 65° C.) for 14 hours to afford the title compound (339.4 g).

1. temperaturebefore cooling to 50° C.
2. temperatureAfter heating
3. temperatureto reflux for 16 hours
4. temperaturewas cooled to 10° C
5. filtrationAfter 30 min the resulting solid was collected by vacuum filtration
6. custompulling dry
7. customto form a cake that
8. customwas dried in a vacuum oven (20 mm Hg, 65° C.) for 14 hours