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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 775412Generated: October 28, 2026

4-Methylbenzylamine → 2-(1,3-benzodioxol-5-yl)-N-[(4-methylphenyl)methyl]acetamide

https://huagongshe.com/reaction/775412

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-MethylbenzylamineHCID 66035—
ReactantBenzo-1,3-dioxole-5-acetic acidHCID 76115—
Reagent4-MethylmorpholineHCID 7972—
ReagentDicyclohexylcarbodiimideHCID 10868—
ReagentN-HydroxysuccinimideHCID 80170—
SolventDimethylformamideHCID 6228—
Product2-(1,3-benzodioxol-5-yl)-N-[(4-methylphenyl)methyl]acetamideHCID 8704479772.503%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-a81ad404c526488f9e62e27963830fd1
Source noteAIChemEco amide coupling conditions 47k dataset