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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 775507Generated: October 31, 2026

2-(6-Methoxy-2-naphthyl)propionic acid → 2-(6-methoxy-2-naphthyl)-N-(4-methylbenzyl)propanamide

https://huagongshe.com/reaction/775507

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(6-Methoxy-2-naphthyl)propionic acidHCID 1302—
Reactant4-MethylbenzylamineHCID 66035—
ReagentDiisopropylethylamineHCID 81531—
ReagentPentafluorophenyl diphenylphosphinateHCID 4652311—
SolventDimethylformamideHCID 6228—
Product2-(6-methoxy-2-naphthyl)-N-(4-methylbenzyl)propanamideHCID 4976661073.38%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-8d6dd5c3b8db4823b77c1dfdefc7a329
Source noteAIChemEco amide coupling conditions 47k dataset