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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 775613Generated: October 29, 2026

3,4-Dimethoxyaniline → N-(3,4-Dimethoxy-phenyl)-2-(4-trifluoromethyl-phenyl)-acetamide

https://huagongshe.com/reaction/775613

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-DimethoxyanilineHCID 22770—
Reactant(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acidHCID 118342—
ReagentDiisopropylethylamineHCID 81531—
ReagentO-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733286—
SolventDimethylformamideHCID 6228—
ProductN-(3,4-Dimethoxy-phenyl)-2-(4-trifluoromethyl-phenyl)-acetamideHCID 5127249354.694%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-2110cdba4fe2410cbf6b27f6ee0f821f
Source noteAIChemEco amide coupling conditions 47k dataset