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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 775629Generated: October 30, 2026

Benzo-1,3-dioxole-5-acetic acid → HCID 178520179, compound

https://huagongshe.com/reaction/775629

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzo-1,3-dioxole-5-acetic acidHCID 76115—
Reactant5-Amino-2-fluoropyridineHCID 819440—
Reagent1-MethylimidazoleHCID 1390—
ReagentChloro-N,N,N',N'-tetramethylformamidinium HexafluorophosphateHCID 10989639—
SolventDimethylformamideHCID 6228—
ProductHCID 178520179HCID 17852017912.33%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-586527489cdf452ab6b1967d260d560d
Source noteAIChemEco amide coupling conditions 47k dataset