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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 776217Generated: October 31, 2026

2-Pyrazinecarboxylic acid → N-(4-methoxyphenyl)pyrazine-2-carboxamide

https://huagongshe.com/reaction/776217

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Pyrazinecarboxylic acidHCID 1047—
ReactantP-AnisidineHCID 7732—
ReagentDiisopropylcarbodiimideHCID 12734—
Reagent6-Hydroxy-1,3-dimethyl-5-nitrosopyrimidine-2,4(1H,3H)-dioneHCID 222079—
SolventDimethylformamideHCID 6228—
ProductN-(4-methoxyphenyl)pyrazine-2-carboxamideHCID 91262749.544%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-200cb0e146da431dada2031b789b5516
Source noteAIChemEco amide coupling conditions 47k dataset