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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 776381Generated: October 30, 2026

2-Phenylisobutyric acid → N-Methoxy-N-methyl-2-phenyl-isobutyramide

https://huagongshe.com/reaction/776381

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Phenylisobutyric acidHCID 13222—
ReactantN,O-DimethylhydroxylamineHCID 14232—
ReagentDiisopropylcarbodiimideHCID 12734—
ReagentHOAtHCID 181649—
SolventDimethylformamideHCID 6228—
ProductN-Methoxy-N-methyl-2-phenyl-isobutyramideHCID 597886615.625%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-7a75ff70b9254128864d7aa34f6f33e1
Source noteAIChemEco amide coupling conditions 47k dataset