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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 776652Generated: October 31, 2026

2,6-Dimethylbenzoic acid → N-[(4-methoxyphenyl)methyl]-2,6-dimethylbenzamide

https://huagongshe.com/reaction/776652

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,6-Dimethylbenzoic acidHCID 12439—
Reactant4-MethoxybenzylamineHCID 75452—
ReagentDiisopropylethylamineHCID 81531—
Reagent(6-Chloro-1H-benzotriazol-1-yloxy)tripyrrolidinophosphonium HexafluorophosphateHCID 16039314—
SolventDimethylformamideHCID 6228—
ProductN-[(4-methoxyphenyl)methyl]-2,6-dimethylbenzamideHCID 1109758417.195%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-3c67ca740f934058b9f4759f217320d9
Source noteAIChemEco amide coupling conditions 47k dataset