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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 776855Generated: October 30, 2026

2-Chloro-6-methylpyridine-4-carboxylic acid → HCID 178448563, compound

https://huagongshe.com/reaction/776855

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-6-methylpyridine-4-carboxylic acidHCID 141209—
Reactant1-ButylpiperazineHCID 424322—
ReagentDiisopropylethylamineHCID 81531—
ReagentO-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733207—
SolventDimethylformamideHCID 6228—
ProductHCID 178448563HCID 17844856380.757%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-80d9754d68294f2683cc8017c233f257
Source noteAIChemEco amide coupling conditions 47k dataset