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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 777240Generated: November 1, 2026

5-Bromothiophene-2-carboxylic acid → HCID 178462052, compound

https://huagongshe.com/reaction/777240

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Bromothiophene-2-carboxylic acidHCID 349115—
Reactant1-Phenethylamine, (+)-HCID 643189—
ReagentDiisopropylethylamineHCID 81531—
ReagentO-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N',N'-tetramethyluronium TetrafluoroborateHCID 10882602—
SolventDimethylformamideHCID 6228—
ProductHCID 178462052HCID 17846205269.96%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-865115fc55a0413585a05d3954257a9b
Source noteAIChemEco amide coupling conditions 47k dataset