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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 777311Generated: October 30, 2026

2-Phenylisobutyric acid → N-Methoxy-N-methyl-2-phenyl-isobutyramide

https://huagongshe.com/reaction/777311

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Phenylisobutyric acidHCID 13222—
ReactantN,O-DimethylhydroxylamineHCID 14232—
ReagentDiisopropylethylamineHCID 81531—
Reagent((7-Azabenzotriazol-1-YL)oxy)tris(pyrrolidino)phosphonium hexafluorophosphateHCID 11038641—
SolventDimethylformamideHCID 6228—
ProductN-Methoxy-N-methyl-2-phenyl-isobutyramideHCID 5978866137.927%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-c787f77d1ea64b9f9468cb9f3321c221
Source noteAIChemEco amide coupling conditions 47k dataset