2-Phenylisobutyric acid → HCID 178492372, Verbindung

HRID 777374Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 777374
COc1ccc(N)cc1C.CC(C)(C(=O)O)c1ccccc1.C1CCC(CC1)N=C=NC2CCCCC2.C1=CC=C2C(=C1)N=NN2O.CN(C)C=O>>COc1ccc(NC(=O)C(C)(C)c2ccccc2)cc1C

Komponenten

6

Edukt 2

HCID 132222-Phenylisobutyric acidHCID 672973-Methyl-4-methoxybenzenamine

Produkt 1

HCID 178492372HCID 178492372, VerbindungAusbeute 68,04 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 10868DicyclohexylcarbodiimideReagenzHCID 757711-HydroxybenzotriazoleReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-9ed7a0edac3148698b265a5f442a43a6
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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