反应详情

To a solution of 3-amino-5-(5-methyl-pyridin-2-yl)-benzoic acid methyl ester (362 mg, 1.51 mmol) and NaN3 (182 g, 2.8 mmol) in AcOH was added HC(OEt)3 (1074 mg, 7.25 mmol) at room temperature. The reaction mixture was heated to reflux for 4 hours and then cooled to room temperature. The solvent was removed in vacuo and the residue was purified by silica-gel chromatography to give 3-(5-methyl-pyridin-2-yl)-5-tetrazol-1-yl-benzoic acid methyl ester as a light yellow solid (440 mg, 100%). MS (M+H)=296.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 4 hours
3. customThe solvent was removed in vacuo
4. customthe residue was purified by silica-gel chromatography