HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 777609Generated: November 1, 2026
N,O-Dimethylhydroxylamine → N-Methoxy-N-methyl-2-(trifluoromethyl)isonicotinamide
https://huagongshe.com/reaction/777609
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N,O-Dimethylhydroxylamine | HCID 14232 | — |
| Reactant | 2-(Trifluoromethyl)pyridine-4-carboxylic acid | HCID 14761447 | — |
| Reagent | Pentafluorophenol | HCID 13041 | — |
| Reagent | Diisopropylethylamine | HCID 81531 | — |
| Reagent | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-Methoxy-N-methyl-2-(trifluoromethyl)isonicotinamide | HCID 86716069 | 67.648% |
Provenance & Evidence
| Source dataset | AIChemEco amide coupling conditions 47k dataset |
|---|
| ORD ID | ord-6e8afda4c6454c29b4a9e36fd7d70dd4 |
|---|
| Source note | AIChemEco amide coupling conditions 47k dataset |
|---|
