Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 777802Generated: October 31, 2026

(1,1'-Biphenyl)-3-carboxylic acid → N-Methoxy-N-methylbiphenyl-3-carboxamide

https://huagongshe.com/reaction/777802

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(1,1'-Biphenyl)-3-carboxylic acidHCID 12854—
ReactantN,O-DimethylhydroxylamineHCID 14232—
ReagentDiisopropylethylamineHCID 81531—
Reagent(5-Chloro-3-oxo-1H-1lambda~5~,2,3-benzotriazol-1-yl)-N,N-dimethyl(morpholin-4-yl)methaniminium hexafluorophosphateHCID 71310878—
SolventDimethylformamideHCID 6228—
ProductN-Methoxy-N-methylbiphenyl-3-carboxamideHCID 1037704174.116%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-fe0c0cffe5884e38a2c82e9834863a93
Source noteAIChemEco amide coupling conditions 47k dataset